Ed,
Please explain what you mean by "does not work". CHIRP runs on Windows XP, Vista, 7, 8, 8.1 and 10. It also runs on computers with Linux and Mac OS X operating systems.
Does CHIRP load?
If no, then disable Smartscreen "(see FAQ 2.2 here)":http://www.miklor.com/COM/UV_CHIRP.php#LoadingCHIRP to see if that makes a difference.
If yes but CHIRP can't download/upload, then the problem is most likely with the programming cable, not CHIRP. No programming software can work unless there is a complete and working connection between the computer and radio. If your programming cable contains a Prolific type USB-to-TTL chip (most under $20 programming cables do), the chance of it being counterfeit is near 100%. The device driver that is auto installed by Windows for a Prolific type chip is intentionally incompatible with counterfeit chips.
One workaround is to download, install and select an older driver. See "this page":http://www.miklor.com/COM/UV_Drivers.php for a link to the driver and instructions for getting it selected.
Another workaround is to get a programming cable with a different type of USB-to-TTL chip. Programming cables with an FTDI type chip are popular because they are nearly 100% plug-and-play with Windows and Mac OS X.
Jim KC9HI