"Radio did not respond" is an indication that there is not connection between the computer and radio. Either the correct device driver is not installed or the plug of the programming cable is not fully inserted into the socket of the radio.
"The system could not find the port specified" The port selected is not available.
"Could not open port USB3 [error 2] The system could not find the port specified" is an indication that the port selected is not correct (definitely wrong because "USBx" will almost never be correct for Windows)
You are not selecting the correct port. The correct port will be COMx where "x" is the port number from 1 to 255. Use the Windows Device Manager application to determine which COM port number has been assigned to your programming cable. Just because a COM port number shows up in the list does not mean it is a COM port number that you should choose. For example COM1 in my computer is an on-board serial port built into my computer's motherboard and has nothing connected to it. So for me COM1 will never be a valid selection for CHIRP.
Try this. With the programming cable unplugged from the computer (and radio), open Device Manager. With Device Manager open plug the USB end of the programming cable into the computer's USB port. Watch Device Manager to see which new entry appears under the "Ports (COM & LPT)" branch of the Device Manager tree. The newly added device will be your programming cable so make a note of COM port number that has been assigned to it.
Also once you have determined the correct COM port number, try to use the same USB port each time you program your computer. Depending on which chip is in your programming cable, the device driver may assign a different COM port number for each USB port (the Prolific driver does this. The FTDI driver keeps it the same). Also avoid using a USB hub with your programming cable.
Please avoid opening a new ticket every time? Follow up and add new information to the existing issue.
Jim KC9HI